HRID2245215

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID7918

Acetic anhydride

C4H6O3

HCID14798

Sodium Hydroxide

HNaO

结构：N[C@H](CCCCNC(=O)OCc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)OCc1ccccc1

HCID131727989

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N[C@H](CCCCNC(=O)OCc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)OCc1ccccc1

HCID131727988

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

The previously obtained chloromethylene solution of HCl, H-D-Lys(Z)-D-Pro-OBzl is cooled down to 5° C., added with 135 ml of water, followed by 32.3 ml of acetic anhydride (1.5 eq). At Qsp pH 10 is then added within 30 minutes to 1 hour an aqueous 5N NaOH (90 to 130 ml are required).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1ed88d2884a14607875fe1095dbff306
来源数据集: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07683026B2
来源说明: uspto-grants-2010_03

反应 SMILES

Cl.[NH2:2][C@@H:3]([C:19]([N:21]1[CH2:35][CH2:34][CH2:33][C@@H:22]1[C:23]([O:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:24])=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10].[C:36](OC(=O)C)(=[O:38])[CH3:37].[OH-].[Na+]>O>[NH:2]([C:36]([CH3:37])=[O:38])[C@@H:3]([C:19]([N:21]1[CH2:35][CH2:34][CH2:33][C@@H:22]1[C:23]([O:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:24])=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10]