Chloroacetone → HCID 23115208, compound

HRID 2245275Notes

Reaction equation

HRID 2245275 reaction equation
[N+:1]([C:4]1[CH:14]=[C:8]2[C:9]([NH:11][C:12](=[O:13])[C:7]2=[CH:6][CH:5]=1)=[O:10])([O-:3])=[O:2].[C:15](=[O:18])([O-])[O-].[K+].[K+].Cl[CH2:22][C:23](=O)[CH3:24]>>[N+:1]([C:4]1[CH:14]=[C:8]2[C:9]([N:11]([CH2:22][C:23](=[C:15]=[O:18])[CH3:24])[C:12](=[O:13])[C:7]2=[CH:6][CH:5]=1)=[O:10])([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 6571Chloroacetone2×HCID 69694-NitrophthalimideHCID 11430Potassium Carbonate

Product 1

HCID 23115208HCID 23115208, compound

Conditions

Temperature
100 °C

Procedure

After 4.0 g of 5-nitro-phthalimide were mixed with 5.74 g of potassium carbonate thoroughly, the resulting mixture was poured into a 25 mL flask followed by adding 6.6 mL of chloroacetone, and heated to 90-110° C. (a reflux condensing tube was needed to be equipped on the flask, the system was protected with argon). After the reaction was conducted for 3-4 hr, excess of chloroacetone was removed under a reduced pressure, into the residue was added a great deal of water, then filtrated with Buchner's filter. The resulting solid was washed twice with 10 ml of 10% NaOH, and 5-6 times with water respectively, dried in vacuum to obtain 5-nitro-N-(2-carbonyl-propyl)-phthalimide;

Workup

  1. additionthe resulting mixture was poured into a 25 mL flask
  2. customa reflux condensing tube
  3. customto be equipped on the flask
  4. customwas removed under a reduced pressure, into the residue
  5. additionwas added a great deal of water
  6. filtrationfiltrated with Buchner's
  7. filtrationfilter
  8. washThe resulting solid was washed twice with 10 ml of 10% NaOH, and 5-6 times with water respectively
  9. customdried in vacuum

Sources & evidence

ORD record
ord-cae3d365fefc42a48fc81594263958b9
Source dataset
uspto-grants-2010_03
Patent number
US07683073B2

Reaction notes

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