HCID 59216591, compound → HCID 59216602, compound

HRID 2245292Notes

Reaction equation

HRID 2245292 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-])=O)[CH:8]=[CH:9][CH:10]=2)[CH2:5][C:4](=[O:15])[CH2:3]1>[Pd].CO>[NH2:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[CH2:5][C:4](=[O:15])[CH2:3][N:2]2[CH3:1]

Participants

4

Reactant 1

HCID 59216591HCID 59216591, compound

Product 1

HCID 59216602HCID 59216602, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 1-methyl-5-nitro-1,4-dihydroquinolin-3(2H)-one and catalytic amount of palladium on carbon in methanol is stirred under hydrogen for 3 hours. The resulting mixture is filtered through a pad of celite, and the filtrate is concentrated under reduced pressure to afford 5-amino-1-methyl-1,4-dihydroquinolin-3(2H)-one

Workup

  1. filtrationThe resulting mixture is filtered through a pad of celite
  2. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-fe41448562874321b0dbfb723894ec74
Source dataset
uspto-grants-2010_03
Patent number
US07683076B2

Reaction notes

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