Hydrochloric Acid → HCID 16063792, compound

Participants

Reaction Steps

2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(8aR) -hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (E25; 39 mg, 0.063 mmol) was dissolved in DCM and the temperature was lowered at 0° C.; HCl (1M soln. in Et2O) 75 μl (0.075 mmol) was slowly added and, afterwards, the reaction mixture was stirred at this temperature for 30 min. Then, the solvent was removed and, the solid obtained was triturated with pentane. Obtained 41 mg of the desired compound as pale yellow solid.

Provenance & Evidence