Hydrochloric Acid → HCID 16063792, compound

HRID 2245475Notes

Reaction equation

HRID 2245475 reaction equation
[F:1][C:2]([F:44])([F:43])[C:3]1[CH:4]=[C:5]([C:13]([CH3:42])([CH3:41])[C:14]([N:16]([C:18]2[CH:19]=[N:20][C:21]([N:32]3[CH2:37][CH2:36][N:35]4[CH2:38][CH2:39][CH2:40][C@@H:34]4[CH2:33]3)=[CH:22][C:23]=2[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=2[CH3:31])[CH3:17])=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[ClH:45]>C(Cl)Cl>[ClH:45].[F:12][C:9]([F:10])([F:11])[C:7]1[CH:6]=[C:5]([C:13]([CH3:42])([CH3:41])[C:14]([N:16]([C:18]2[CH:19]=[N:20][C:21]([N:32]3[CH2:37][CH2:36][N:35]4[CH2:38][CH2:39][CH2:40][C@@H:34]4[CH2:33]3)=[CH:22][C:23]=2[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=2[CH3:31])[CH3:17])=[O:15])[CH:4]=[C:3]([C:2]([F:1])([F:43])[F:44])[CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 16063766HCID 16063766, compound

Product 1

HCID 16063792HCID 16063792, compoundYield 98.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(8aR) -hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (E25; 39 mg, 0.063 mmol) was dissolved in DCM and the temperature was lowered at 0° C.; HCl (1M soln. in Et2O) 75 μl (0.075 mmol) was slowly added and, afterwards, the reaction mixture was stirred at this temperature for 30 min. Then, the solvent was removed and, the solid obtained was triturated with pentane. Obtained 41 mg of the desired compound as pale yellow solid.

Workup

  1. customwas lowered at 0° C.
  2. customThen, the solvent was removed
  3. customthe solid obtained
  4. customwas triturated with pentane

Sources & evidence

ORD record
ord-38a6cf0351074a4fb1c913cb325c0f79
Source dataset
uspto-grants-2010_03
Patent number
US07683056B2

Reaction notes

Loading…