Hydrochloric Acid → 2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(2-chloro-4-fluorophenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(2-chloro-4-fluorophenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide	HCID 16063949	—
Product	2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(2-chloro-4-fluorophenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide hydrochloride	HCID 16063950	—

Reaction Steps

HCl salt made according to method described in Example 41 starting from 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(2-chloro-4-fluorophenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (E47, 10 mg) to afford a pale yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07683056B2
Source dataset	uspto-grants-2010_03
ORD ID	ord-9f0b2c17070b465ca520f1ddfcbf4803
Source note	uspto-grants-2010_03