Hydrochloric Acid → 2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(2-chloro-4-fluorophenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide hydrochloride

HRID 2245490Notes

Reaction equation

HRID 2245490 reaction equation
Cl.[F:2][C:3]([F:48])([F:47])[C:4]1[CH:5]=[C:6]([C:14]([CH3:46])([CH3:45])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=2[Cl:32])[CH3:18])=[O:16])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1>>[ClH:32].[F:48][C:3]([F:2])([F:47])[C:4]1[CH:5]=[C:6]([C:14]([CH3:46])([CH3:45])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=2[Cl:32])[CH3:18])=[O:16])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 160639492-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(2-chloro-4-fluorophenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide

Product 1

HCID 160639502-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(2-chloro-4-fluorophenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide hydrochloride

Procedure

HCl salt made according to method described in Example 41 starting from 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(2-chloro-4-fluorophenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (E47, 10 mg) to afford a pale yellow solid.

Workup

  1. customto afford a pale yellow solid

Sources & evidence

ORD record
ord-9f0b2c17070b465ca520f1ddfcbf4803
Source dataset
uspto-grants-2010_03
Patent number
US07683056B2

Reaction notes

Loading…