HRID2245517

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID523102

p-(Trifluoromethoxy)benzenesulphonyl chloride

C7H4ClF3O3S

结构：CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Cn2ccc3cc(N)ccc32)cc1

HCID68548160

未命名化合物

PRODUCTS

生成物

结构：O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Cn2ccc3cc(NS(=O)(=O)c4ccc(OC(F)(F)F)cc4)ccc32)cc1

HCID16113885

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from ethyl N-{4-[(5-amino-1H-indol-1-yl)methyl]benzoyl}phenylalaninate and 4-trifluoromethoxyphenyl sulfonyl chloride following the procedure of Example 10: MS (ESI) m/z 638; MS (ESI) m/z 636.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-574681e9cd4a4a3d9ffe5916382a1728
来源数据集: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07683091B2
来源说明: uspto-grants-2010_03

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:33]=[CH:32][C:15]([C:16]([NH:18][C@H:19]([C:27]([O:29]CC)=[O:28])[CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[O:17])=[CH:14][CH:13]=1)[CH:6]=[CH:5]2.[F:34][C:35]([F:48])([F:47])[O:36][C:37]1[CH:42]=[CH:41][C:40]([S:43](Cl)(=[O:45])=[O:44])=[CH:39][CH:38]=1>>[F:48][C:35]([F:34])([F:47])[O:36][C:37]1[CH:42]=[CH:41][C:40]([S:43]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[N:7]([CH2:11][C:12]2[CH:33]=[CH:32][C:15]([C:16]([NH:18][C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[O:17])=[CH:14][CH:13]=2)[CH:6]=[CH:5]3)(=[O:45])=[O:44])=[CH:39][CH:38]=1