HCID 10214443, compound → HCID 135514435, compound

HRID 2245572Notes

Reaction equation

HRID 2245572 reaction equation
[Cl:1][C:2]1[N+:7]([O-])=[CH:6][C:5]([CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[CH3:16][NH:17][C:18]([C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][C:24](=[O:29])[CH2:23]2)=[O:19]>>[ClH:1].[OH:29][C:24]1[NH:25][C:26]2[C:22]([C:23]=1[C:2]1[CH:3]=[CH:4][C:5]([CH2:9][N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)=[CH:6][N:7]=1)=[CH:21][C:20]([C:18]([NH:17][CH3:16])=[O:19])=[CH:28][CH:27]=2

Participants

3

Reactant 2

HCID 10214443HCID 10214443, compoundHCID 85873132HCID 85873132, compound

Product 1

HCID 135514435HCID 135514435, compoundYield 12%

Procedure

The title compound was prepared as described for Example 101 using 4-[(6-chloro-1-oxidopyridin-3-yl)methyl]morpholine and N-methyl-2-oxoindoline-5-carboxamide. Yield: 12%: 1H NMR (D2O, 400 MHz) δ 7.82 (d, J=2 Hz, 1H), 7.58 (dd, J=9, 2 Hz, 1H), 7.45 (br s, 1H), 7.28 (m, 2H), 6.92 (d, J=8 Hz, 1H), 4.16 (s, 2H), 4.12 (m, 2H), 3.79 (m, 2H), 3.46 (m, 2H), 3.24 (m, 2H), 2.90 (s, 3H); MS (TSP) m/z 367 (M++1).

Sources & evidence

ORD record
ord-a39319fa89d74b579f6efb801cf37488
Source dataset
uspto-grants-2010_03
Patent number
US07683067B2

Reaction notes

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