Hydrochloric Acid → L-Pipecolic acid hydrochloride

Participants

Reaction Steps

A solution of 150 g of L-pipecolinic acid (1170 mmol) in methanol (3000 ml) was stirred at room temperature for 10 to 15 min, after which was added 900 mL of saturated methanolic HCl slowly over a period of 20 to 30 min; stirring continued until a clear solution was formed (after about 20 to 30 min). The methanol was then removed by vacuum distillation and the solid obtained was dried to give pure L-pipecolic acid hydrochloride (192.3 g)

Provenance & Evidence