Hydrochloric Acid → L-Pipecolic acid hydrochloride

HRID 2245609Notes

Reaction equation

HRID 2245609 reaction equation
[CH2:1]1[CH2:6][C@@H:5]([C:7]([OH:9])=[O:8])[NH:4][CH2:3][CH2:2]1.[ClH:10]>CO>[CH2:1]1[CH2:6][C@@H:5]([C:7]([OH:9])=[O:8])[NH:4][CH2:3][CH2:2]1.[ClH:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 439227Pipecolic acid, (-)-

Product 1

HCID 12210878L-Pipecolic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 150 g of L-pipecolinic acid (1170 mmol) in methanol (3000 ml) was stirred at room temperature for 10 to 15 min, after which was added 900 mL of saturated methanolic HCl slowly over a period of 20 to 30 min; stirring continued until a clear solution was formed (after about 20 to 30 min). The methanol was then removed by vacuum distillation and the solid obtained was dried to give pure L-pipecolic acid hydrochloride (192.3 g)

Workup

  1. customwas formed (after about 20 to 30 min)
  2. customThe methanol was then removed by vacuum distillation
  3. customthe solid obtained
  4. customwas dried

Sources & evidence

ORD record
ord-9e879d98dbd949efb7b6b329a6ed2281
Source dataset
uspto-grants-2010_03
Patent number
US07683175B2

Reaction notes

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