反应详情

温度

50 °C

About 2 g of Ropivacaine base was dissolved in a mixture of 2.6 mL of concentrated hydrochloride acid and 5 mL of water at about 30° C. This mixture was stirred at a temperature of about 50° C. for about 30 min and then hot acetone (100 ml) was added. The mixture was then held at about 0 to 5° C. and stirring continued for about 2 hr. A precipitated solid was filtered, washed with acetone, and then dried under vacuum at about 35° C. for about 6 hr. 2.1 g, yield 93%, water content: 5.5%. All water contents herein are determined by Karl Fisher titration.

1. customwas then held at about 0 to 5° C.
2. stirringstirring
3. waitcontinued for about 2 hr
4. filtrationA precipitated solid was filtered
5. washwashed with acetone
6. customdried under vacuum at about 35° C. for about 6 hr