反应详情

温度

85 °C

About 2 g of Ropivacaine base was dissolved in a mixture of 2.6 mL of concentrated hydrochloride acid and 40 mL of water. The solution was heated to about 85° C. and stirred for about 30 min to get a clear solution and cooled to about 5° C. and continued stirring for about 2 hr. A precipitated solid was recovered and filtered, then washed with acetone and dried under vacuum at about 35° C. for about 6 hr. Results: wt 2.0 g, yield 88.5 %; water content: 5.5%. The x-ray diffraction pattern of the material obtained is shown in FIG. 1.

1. customto get a clear solution
2. temperaturecooled to about 5° C.
3. stirringcontinued stirring for about 2 hr
4. customA precipitated solid was recovered
5. filtrationfiltered
6. washwashed with acetone
7. customdried under vacuum at about 35° C. for about 6 hr
8. customResults
9. customThe x-ray diffraction pattern of the material obtained