Acetone → L-ropivacaine hydrochloride monohydrate

Participants

Reaction Steps

About 2 g of Ropivacaine base was dissolved in 10 mL of water and 7.3 mL of concentrated hydrochloride acid was added slowly with stirring and 350 mL of acetone was added and kept at about 0° C. for 2 days. The precipitated solid was filtered, washed with acetone, and dried under vacuum at about 35° C. for about 6 hr: 1.8 g; yield 79%; water content of 5.6%.

Provenance & Evidence