反应详情

About 2 g of Ropivacaine base was dissolved in 10 mL of water and 7.3 mL of concentrated hydrochloride acid was added slowly with stirring and 350 mL of acetone was added and kept at about 0° C. for 2 days. The precipitated solid was filtered, washed with acetone, and dried under vacuum at about 35° C. for about 6 hr: 1.8 g; yield 79%; water content of 5.6%.

1. filtrationThe precipitated solid was filtered
2. washwashed with acetone
3. customdried under vacuum at about 35° C. for about 6 hr