反应详情

About 3 g of Ropivacaine base was dissolved in 10 mL of water and to this solution was added 50 mL of hot acetone and conc. Hydrochloride acid was added slowly with stirring until pH reaches 2 and heated to reflux until the solution becomes clear solution. 20 mL of acetone was added and the precipitated solid was filtered, washed with acetone and dried to give L-Ropivacaine hydrochloride monohydrate 2.9 g, yield 82% Water content: 5.6%

1. additionwas added slowly
2. temperatureheated
3. temperatureto reflux until the solution
4. filtrationthe precipitated solid was filtered
5. washwashed with acetone
6. customdried