Hydrochloric Acid → Lercanidipine

HRID 2245624Notes

Reaction equation

HRID 2245624 reaction equation
[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][C:12]([CH2:15][N:16]([CH2:18][CH2:19][CH:20]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH3:17])([CH3:14])[CH3:13])=[O:10])[CH:4]([C:33]2[CH:34]=[CH:35][CH:36]=[C:37]([N+:39]([O-:41])=[O:40])[CH:38]=2)[C:3]=1[C:42]([O:44][CH3:45])=[O:43].S(C1C=CC=CC=1)([O-])(=O)=O.Cl>>[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][C:12]([CH2:15][N:16]([CH2:18][CH2:19][CH:20]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH3:17])([CH3:13])[CH3:14])=[O:10])[CH:4]([C:33]2[CH:34]=[CH:35][CH:36]=[C:37]([N+:39]([O-:41])=[O:40])[CH:38]=2)[C:3]=1[C:42]([O:44][CH3:45])=[O:43]

Participants

3

Reactant 2

HCID 313Hydrochloric Acid3×HCID 131727996HCID 131727996, compound2×

Product 1

HCID 65866Lercanidipine

Procedure

The solubility of crystalline lercanidipine besylate, napadisylate and hydrochloride and amorphous lercanidipine besylate was evaluated by UV-Visible spectroscopy in aqueous 0.1 M HCl (pH 1) at 22° C. Suspensions of approximately 0.3 mg/ml of the respective compounds were prepared in an aqueous 0.1 M HCl and equilibrated by shaking for 24 hours. Following equilibration, the samples were filtered (0.1 μm filter) and the concentration was determined photometrically using Perkin Elmer Lambda 16 (Überlingen, Germany). Reference measurements were performed with 20% acetonitrile as a co-solvent.

Workup

  1. filtrationthe samples were filtered
  2. filtration(0.1 μm filter)
  3. concentrationthe concentration

Sources & evidence

ORD record
ord-8210286fec114d4aa344e2aa66b46dac
Source dataset
uspto-grants-2010_03
Patent number
US07683179B2

Reaction notes

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