Hydrochloric Acid → HCID 68617696, compound

HRID 2245633Notes

Reaction equation

HRID 2245633 reaction equation
[CH:1]([C:4]1[S:8][C:7]([NH:9][S:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3([CH2:25][NH:26]C(=O)C)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[CH:15][CH:14]=2)(=[O:12])=[O:11])=[N:6][N:5]=1)([CH3:3])[CH3:2].[ClH:30]>>[ClH:30].[NH2:26][CH2:25][C:19]1([C:16]2[CH:15]=[CH:14][C:13]([S:10]([NH:9][C:7]3[S:8][C:4]([CH:1]([CH3:3])[CH3:2])=[N:5][N:6]=3)(=[O:12])=[O:11])=[CH:18][CH:17]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59216848HCID 59216848, compound

Product 1

HCID 68617696HCID 68617696, compound

Procedure

1 g of N-{1-[4-(5-isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-cyclohexylmethyl}-acetamide was suspended in 25 ml five molar hydrochloric acid and heated under reflux for 20 hours. The cooled reaction mixture was evaporated in vacuo. The residue was purified by chromatography on silica gel with the eluents dichloromethane:methanol=95:5 to obtain 0.78 g of a with solid.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 20 hours
  3. customThe cooled reaction mixture
  4. customwas evaporated in vacuo
  5. customThe residue was purified by chromatography on silica gel with the eluents dichloromethane
  6. custommethanol=95:5 to obtain 0.78 g of a with solid

Sources & evidence

ORD record
ord-9538caa5b17044cc84724318b2cc8a04
Source dataset
uspto-grants-2010_03
Patent number
US07683181B2

Reaction notes

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