反应详情

1 g of N-{1-[4-(5-isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-cyclohexylmethyl}-acetamide was suspended in 25 ml five molar hydrochloric acid and heated under reflux for 20 hours. The cooled reaction mixture was evaporated in vacuo. The residue was purified by chromatography on silica gel with the eluents dichloromethane:methanol=95:5 to obtain 0.78 g of a with solid.

1. temperatureheated
2. temperatureunder reflux for 20 hours
3. customThe cooled reaction mixture
4. customwas evaporated in vacuo
5. customThe residue was purified by chromatography on silica gel with the eluents dichloromethane
6. custommethanol=95:5 to obtain 0.78 g of a with solid