反应详情

Dextro amphetamine (200 g) and triethylamine (164 g) were dissolved in 1500 ml. of benzene. A solution of p-toluene sulfonyl chloride (310g) in 500 ml. of benzene was added dropwise to the cooled solution during one hour. The reaction mixture was stirred for three hours at room temperature, then allowed to stand for approximately 16 hours (over night) at room temperature (approximately 20° C.). The salts were filtered off and the benzene solution was washed with dilute HCl, water and brine. Evaporation of the solvent afforded an oil.

1. waitto stand for approximately 16 hours
2. customat room temperature
3. custom(approximately 20° C.)
4. filtrationThe salts were filtered off
5. washthe benzene solution was washed with dilute HCl, water and brine
6. customEvaporation of the solvent
7. customafforded an oil