反应详情

温度

80 °C

2-Methyl-4-(1-methyl-cyclopropyl)-benzoic acid methyl ester (2.75 g, 13.46 mmol) was treated with methanol and 5 M aqueous sodium hydroxide solution (20.46 ml, 102.32 mmol). This solution was heated to 80° C. for 4 hours. The reaction mixture was concentrated until methanol was evaporated. A white solid was obtained. The solid was dissolved in 50 ml water under heating then cooled with an ice bath; acidified with 10 ml conc. hydrochloric acid. A white precipitate was formed; filtered; washed with water; dried under high vacuum over night to yield 2-Methyl-4-(1-methyl-cyclopropyl)-benzoic acid (2.18 g, 11.46 mmol) MS (ESI) 189.1 (M−H)−

1. concentrationThe reaction mixture was concentrated until methanol
2. customwas evaporated
3. customA white solid was obtained
4. temperatureunder heating
5. temperaturethen cooled with an ice bath
6. customA white precipitate was formed
7. filtrationfiltered
8. washwashed with water
9. customdried under high vacuum over night