HCID 12876540, compound → HCID 54415494, compound

Participants

Reaction Steps

To 79 g (0.4 mol) of 6-amino-1-(2-hydroxypropyl)-3-methyl- 2,4-(1H, 3H)-pyrimidinedione (IV), dissolved in 500 ml of ethanol, was added 30 g NaNO2 (0.43 mol) which was dissolved in water, whereafter 36 ml conc. hydrochloric acid was added. The red crystals were dissolved through boiling and the sodium chloride was filtered off. The red filtrate was used for synthetizing 5,6-diamino-1-(2-hydroxypropyl)-3-methyl-2,4-(1H, 3H)-pyrimidinedione (VI) NMR.

Provenance & Evidence