HCID 12876540, compound → HCID 54415494, compound

HRID 224580Notes

Reaction equation

HRID 224580 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][CH:9]([OH:11])[CH3:10])[C:6](=[O:12])[N:5]([CH3:13])[C:4](=[O:14])[CH:3]=1.[N:15]([O-])=[O:16].[Na+]>C(O)C.O.Cl>[NH2:1][C:2]1[N:7]([CH2:8][CH:9]([OH:11])[CH3:10])[C:6](=[O:12])[N:5]([CH3:13])[C:4](=[O:14])[C:3]=1[N:15]=[O:16]

Participants

6

Reactant 2

HCID 12876540HCID 12876540, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 54415494HCID 54415494, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To 79 g (0.4 mol) of 6-amino-1-(2-hydroxypropyl)-3-methyl- 2,4-(1H, 3H)-pyrimidinedione (IV), dissolved in 500 ml of ethanol, was added 30 g NaNO2 (0.43 mol) which was dissolved in water, whereafter 36 ml conc. hydrochloric acid was added. The red crystals were dissolved through boiling and the sodium chloride was filtered off. The red filtrate was used for synthetizing 5,6-diamino-1-(2-hydroxypropyl)-3-methyl-2,4-(1H, 3H)-pyrimidinedione (VI) NMR.

Workup

  1. additionwas added
  2. dissolutionThe red crystals were dissolved through boiling
  3. filtrationthe sodium chloride was filtered off

Sources & evidence

ORD record
ord-55e955069a064dc9912019e2135b9da7
Source dataset
uspto-grants-1980_11
Patent number
US04233303

Reaction notes

Loading…