反应详情

温度

0 °C

Hydrazine hydrate (0.28 mL, 0.0057 mol) was added to a suspension of 3-chloro-6-(4-fluorophenyl)-1,2,4-triazine (400 mg, 0.002 mol) in pyridine (4 mL) at 0° C. and stirred at 0° C. until a precipitate formed. The mixture was then heated at 65° C. for 30 min. The solvent was evaporated under reduced pressure. The residue was triturated with water, filtered, and washed with water. The crystalline solid was collected and dried under high vacuum to give the desired product (360 mg, 91.9%). Analytical LCMS: (M+H)+=206.1.

1. customformed
2. temperatureThe mixture was then heated at 65° C. for 30 min
3. customThe solvent was evaporated under reduced pressure
4. customThe residue was triturated with water
5. filtrationfiltered
6. washwashed with water
7. customThe crystalline solid was collected
8. customdried under high vacuum