反应详情

A mixture of 11.88 g of 4,8 dichloroquinoline, 10.4 g of methyl 2-amino-5-fluoro-benzoate and 60 ml of 2 N hydrochloric acid was refluxed for 21/2 hours and was then cooled to ≃0° C. and vacuum filtered. The moist residue was dissolved in 125 ml of lukewarm methanol and triethylamine was added to the resulting solution to make the pH alkaline. The mixture stood overnight at room temperature and was vacuum filtered and the recovered product was washed with water and dried to obtain 8.3 g of raw product which was crystallized from methanol to obtain 7.39 g of methyl 2-(8-chloro-4-quinolinylamino)-5-fluoro-benzoate melting at 196° C.

1. temperaturewas refluxed for 21/2 hours
2. temperaturewas then cooled
3. customto ≃0° C.
4. filtrationvacuum filtered
5. dissolutionThe moist residue was dissolved in 125 ml of lukewarm methanol
6. additiontriethylamine was added to the resulting solution
7. filtrationfiltered
8. washthe recovered product was washed with water
9. customdried
10. customto obtain 8.3 g of raw product which
11. customwas crystallized from methanol