反应详情

67 g (0.41 mol) p-cumaric acid were added to a mixture of 50.4 g (0.90 mol) potassium hydroxide and 600 ml water. 53.1 g (0.50 mol) ethyl chloroformate were added dropwise at 0° C. The reaction temperature rose to 10° C. The reaction mixture was subsequently allowed to react for 2 h at 25° C. and acidified to pH=1 with 200 ml hydrochloric acid 7 N. The product was filtered off, washed with water and dried under vacuum to give 95.3 g of (2E)-3-{4-[(ethoxycarbonyl)oxy]phenyl}acrylic acid as white powder.

1. customrose to 10° C
2. customto react for 2 h at 25° C.
3. filtrationThe product was filtered off
4. washwashed with water
5. customdried under vacuum