Methyl iodide → HCID 54703139, compound

HRID 224604Notes

Reaction equation

HRID 224604 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:10](=[O:12])(=[O:11])[NH:9][C:8]([C:13]([O:15][CH3:16])=[O:14])=[C:7]([OH:17])[C:6]=2[CH:18]=1.[CH3:19]I.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:10](=[O:11])(=[O:12])[N:9]([CH3:19])[C:8]([C:13]([O:15][CH3:16])=[O:14])=[C:7]([OH:17])[C:6]=2[CH:18]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 54703406HCID 54703406, compound

Product 1

HCID 54703139HCID 54703139, compoundYield 81.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

14.5 gm (50 millimols) of methyl 6-chloro-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide were reacted with 21.3 gm (150 millimols) of methyl iodide and 50 ml of 1N sodium hydroxide in 165 ml of methanol, yielding 12.35 gm (81% of theory) of methyl 6-chloro-4-hydroxy-2-methyl-2H-1, 2-benzothiazine-3-carboxylate-1,1-dioxide.

Sources & evidence

ORD record
ord-3acd6f6cbf604ffcb17e6f07fe7ca451
Source dataset
uspto-grants-1980_11
Patent number
US04233299

Reaction notes

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