Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | HCID 69538043 | HCID 69538043 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68576139 | HCID 68576139 | — |
Reaction Steps
3.4 g (0.0082 mol) of ethyl (2S,3R)-2-(4-fluoro-2-trifluoromethylbenzoylamino)-3-hydroxy-3-o-tolylpropionate were dissolved in ethanol. Methylamine gas was introduced at room temperature. After 1.5 h, the mixture was warmed to 30-35° C. for 1 h. Removal of the solvents gave 3.1 g of the title compound as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07687435B2 |
|---|
| Source dataset | uspto-grants-2010_03 |
|---|
| ORD ID | ord-a9699dc0166e4ba2ac20abc3d4d64a2c |
|---|
| Source note | uspto-grants-2010_03 |
|---|
