Methylamine → HCID 68576139, compound

HRID 2246049Notes

Reaction equation

HRID 2246049 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][C:5]([C:6]([NH:8][C@@H:9]([C@H:15]([OH:23])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[C:10](OCC)=[O:11])=[O:7])=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.[CH3:30][NH2:31]>C(O)C>[CH3:30][NH:31][C:10](=[O:11])[C@@H:9]([NH:8][C:6](=[O:7])[C:5]1[CH:24]=[CH:25][C:2]([F:1])=[CH:3][C:4]=1[C:26]([F:29])([F:28])[F:27])[C@H:15]([OH:23])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH3:22]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 69538043HCID 69538043, compound

Product 1

HCID 68576139HCID 68576139, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
32.5 °C

Procedure

3.4 g (0.0082 mol) of ethyl (2S,3R)-2-(4-fluoro-2-trifluoromethylbenzoylamino)-3-hydroxy-3-o-tolylpropionate were dissolved in ethanol. Methylamine gas was introduced at room temperature. After 1.5 h, the mixture was warmed to 30-35° C. for 1 h. Removal of the solvents gave 3.1 g of the title compound as colorless crystals.

Workup

  1. customRemoval of the solvents

Sources & evidence

ORD record
ord-a9699dc0166e4ba2ac20abc3d4d64a2c
Source dataset
uspto-grants-2010_03
Patent number
US07687435B2

Reaction notes

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