Ammonia → 2-Bromo-1,3-thiazole-4-carboxamide

HRID 2246090Notes

Reaction equation

HRID 2246090 reaction equation
[NH3:1].[Br:2][C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10]CC)=O)[N:7]=1>C1COCC1>[Br:2][C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:10])[NH2:1])[N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 353965Ethyl 2-bromo-1,3-thiazole-4-carboxylate

Product 1

HCID 457896322-Bromo-1,3-thiazole-4-carboxamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

THF (10 ml) and 20 ml of 30% aqueous ammonia were added to 1.51 g of 2-bromo-4-ethoxycarbonylthiazole, and the mixture was stirred at room temperature for 3 days. The reaction solution was concentrated to give 1.31 g of 2-bromo-4-carbamoylthiazole.

Workup

  1. concentrationThe reaction solution was concentrated

Sources & evidence

ORD record
ord-61fcef2fcf5045e2a8d1c171b9c675ac
Source dataset
uspto-grants-2010_03
Patent number
US07687490B2

Reaction notes

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