反应详情

The 2-chloro-3-methoxypyridine (2) (13 g, 90.6 mmol), from Step I, was stirred with 3-equivalents of sodium methoxide (14.7 g, 271.8 mmol) in dimethylformamide (100 mL) at 100° C. until completion of the reaction. The reaction mixture was then quenched with water and extracted with dichloromethane. The combined extracts were washed with water, concentrated and distilled (74° C.; 5 mm Hg) to give the product, 2,3-dimethoxypyridine (3), as a clear oil (7 g; 29% yield for two steps).

1. customThe reaction mixture was then quenched with water
2. extractionextracted with dichloromethane
3. washThe combined extracts were washed with water
4. concentrationconcentrated
5. distillationdistilled (74° C.; 5 mm Hg)