2-Fluorophenol → HCID 11531212, compound

HRID 2246255Notes

Reaction equation

HRID 2246255 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[N:13]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[S:15][C:14]=1[NH2:22].[F:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[OH:30]>>[F:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:22][C:14]1[S:15][C:16]2[C:21]([N:13]=1)=[CH:20][CH:19]=[CH:18][N:17]=2

Participants

4

Reactant 3

HCID 97072-FluorophenolHCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amineHCID 111738094-Chloro-6-iodoquinazoline

Product 1

HCID 11531212HCID 11531212, compound

Procedure

The compound of Example 8 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-iodo-quinazoline, thiazolo[5,4-b]pyridin-2-yl-amine and 2-fluorophenol.

Sources & evidence

ORD record
ord-f6f97f9fcd884e338b32c3fb66943089
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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