Isopropanol → (6-Isopropoxy-quinazolin-4-yl)-thiazolo[5,4-b]pyridin-2-yl-amine
Reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[N:13]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[S:15][C:14]=1[NH2:22].[CH3:23][CH:24](O)[CH3:25]>>[CH:24]([O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:22][C:14]1[S:15][C:16]2[C:21]([N:13]=1)=[CH:20][CH:19]=[CH:18][N:17]=2)([CH3:25])[CH3:23]Participants
4
Procedure
The compound of Example 24 was manufactured by the same method as in Example 22, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-hydroxy-quinazoline, 2-propanol and thiazolo[5,4-b]pyridin-2-yl-amine.
Sources & evidence
- ORD record
- ord-ea54bd2a8ab84d158b9d0c677f43e83f
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07687502B2
Reaction notes
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