Cyclopentanol → (6-Cyclopentyloxy-quinazolin-4-yl)-thiazolo[5,4-b]-pyridin-2-yl-amine

HRID 2246269Notes

Reaction equation

HRID 2246269 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH:13]1(O)[CH2:17][CH2:16][CH2:15][CH2:14]1.[N:19]1[C:27]2[C:22](=[N:23][CH:24]=[CH:25][CH:26]=2)[S:21][C:20]=1[NH2:28]>>[CH:13]1([O:12][C:9]2[CH:10]=[C:11]3[C:6](=[CH:7][CH:8]=2)[N:5]=[CH:4][N:3]=[C:2]3[NH:28][C:20]2[S:21][C:22]3[C:27]([N:19]=2)=[CH:26][CH:25]=[CH:24][N:23]=3)[CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 7298CyclopentanolHCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 11653455(6-Cyclopentyloxy-quinazolin-4-yl)-thiazolo[5,4-b]-pyridin-2-yl-amine

Procedure

The compound of Example 26 was manufactured by the same method as in Example 22, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-hydroxy-quinazoline, cyclopentanol and thiazolo[5,4-b]pyridin-2-yl-amine.

Sources & evidence

ORD record
ord-300dad7b748547388954b41f83e39d90
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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