1,3-Difluoro-2-propanol → [6-(2-Fluoro-1-fluoromethyl-ethoxy)-quinazolin-4-yl]-isoxazol-3-yl-amine

HRID 2246270Notes

Reaction equation

HRID 2246270 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[F:13][CH2:14][CH:15](O)[CH2:16][F:17].[NH2:19][C:20]1[CH:24]=[CH:23][O:22][N:21]=1>>[F:13][CH2:14][CH:15]([CH2:16][F:17])[O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:19][C:20]1[CH:24]=[CH:23][O:22][N:21]=1

Participants

4

Reactant 3

HCID 679851,3-Difluoro-2-propanolHCID 18102163-IsoxazolamineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 11529611[6-(2-Fluoro-1-fluoromethyl-ethoxy)-quinazolin-4-yl]-isoxazol-3-yl-amine

Procedure

The compound of Example 28 was manufactured by the same method as in Example 22, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-hydroxy-quinazoline, 1,3-difluoro-2-propanol and 3-aminoisoxazole.

Sources & evidence

ORD record
ord-9f2f5c4ffeda4afd9cb0aeb79580ae1f
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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