HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Difluoro-2-propanol → [6-(2-Fluoro-1-fluoromethyl-ethoxy)-quinazolin-4-yl]-isoxazol-3-yl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Difluoro-2-propanol | HCID 67985 | — |
| Reactant | 3-Isoxazolamine | HCID 1810216 | — |
| Reactant | 4-Chloroquinazolin-6-ol | HCID 23160273 | — |
| Product | [6-(2-Fluoro-1-fluoromethyl-ethoxy)-quinazolin-4-yl]-isoxazol-3-yl-amine | HCID 11529611 | — |
Reaction Steps
The compound of Example 28 was manufactured by the same method as in Example 22, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-hydroxy-quinazoline, 1,3-difluoro-2-propanol and 3-aminoisoxazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687502B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-9f2f5c4ffeda4afd9cb0aeb79580ae1f |
| Source note | uspto-grants-2010_03 |