1-Methyl-3-aminopyrazole → [6-(3-Cyano-pyridin-2-ylsulfanyl)-pyrido[3,2-d]-pyrimidin-4-yl]-(1-methyl-1H-pyrazol-3-yl)-amine

HRID 2246296Notes

Reaction equation

HRID 2246296 reaction equation
[C:1]([C:3]1[C:4]([SH:9])=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[NH2:10][C:11]1[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=1.Cl[C:18]1[C:19]2[N:27]=[C:26](Cl)[CH:25]=[CH:24][C:20]=2[N:21]=[CH:22][N:23]=1>>[C:1]([C:3]1[C:4]([S:9][C:26]2[CH:25]=[CH:24][C:20]3[N:21]=[CH:22][N:23]=[C:18]([NH:10][C:11]4[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=4)[C:19]=3[N:27]=2)=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2]

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 105841654,6-Dichloropyrido[3,2-d]pyrimidineHCID 178510023HCID 178510023, compound

Product 1

HCID 23160270[6-(3-Cyano-pyridin-2-ylsulfanyl)-pyrido[3,2-d]-pyrimidin-4-yl]-(1-methyl-1H-pyrazol-3-yl)-amine

Procedure

The compound of Example 60 was manufactured by the same method as in Example 31, by a similar method thereto or by a combination of such a method with a conventional method using 3-cyano-2-mercapto-pyridine, 3-amino-1-methyl-1H-pyrazole and 4,6-dichloro-pyrido[3,2-d]pyrimidine.

Sources & evidence

ORD record
ord-c7c2a5113cfc41e2b230fd2470793b00
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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