2-Amino-4-methylthiazole → HCID 11660390, compound

HRID 2246300Notes

Reaction equation

HRID 2246300 reaction equation
[SH:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][N:3]=1.[NH2:8][C:9]1[S:10][CH:11]=[C:12]([CH3:14])[N:13]=1.Cl[C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23](I)[CH:24]=2)[N:19]=[CH:18][N:17]=1>>[CH3:14][C:12]1[N:13]=[C:9]([NH:8][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([S:1][C:2]4[N:6]([CH3:7])[CH:5]=[N:4][N:3]=4)[CH:24]=3)[N:19]=[CH:18][N:17]=2)[S:10][CH:11]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 111738094-Chloro-6-iodoquinazolineHCID 178481306HCID 178481306, compound

Product 1

HCID 11660390HCID 11660390, compound

Procedure

The compound of Example 67 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 3-mercapto-4-methyl-[1,2,4]triazole, 2-amino-4-methyl-1,3-thiazole and 4-chloro-6-iodoquinazoline.

Sources & evidence

ORD record
ord-3d860035344247339ef39be44f272d28
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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