1,2,4-Trifluorobenzene → 6-(2,4-difluorophenoxy)-N-(1-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

HRID 2246312Notes

Reaction equation

HRID 2246312 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[F:9].[NH2:10][C:11]1[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=1.Cl[C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([OH:28])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[F:9][C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[O:28][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[N:21]=[CH:20][N:19]=[C:18]2[NH:10][C:11]1[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=1

Participants

4

Reactant 3

HCID 677731,2,4-TrifluorobenzeneHCID 1372541-Methyl-3-aminopyrazoleHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 116100326-(2,4-difluorophenoxy)-N-(1-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

Procedure

The compound of Example 92 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 1,2,4-trifluorobenzene, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-432ed69eeaf24c82a1f3aaefd243d76d
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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