3-Fluoropyridine → HCID 23160352, compound

HRID 2246325Notes

Reaction equation

HRID 2246325 reaction equation
F[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:8][C:9]1[CH:13]=[CH:12][N:11]([CH3:14])[N:10]=1.Cl[C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([OH:26])[CH:24]=2)[N:19]=[CH:18][N:17]=1>>[CH3:14][N:11]1[CH:12]=[CH:13][C:9]([NH:8][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([O:26][C:2]4[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=4)[CH:24]=3)[N:19]=[CH:18][N:17]=2)=[N:10]1

Participants

4

Reactant 3

HCID 677943-FluoropyridineHCID 1372541-Methyl-3-aminopyrazoleHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160352HCID 23160352, compound

Procedure

The compound of Example 117 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 3-fluoropyridine, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-7e49fb79340d4c7c90530d72cb8bd31f
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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