2-Chloro-3-methylpyridine → HCID 23160276, compound

HRID 2246328Notes

Reaction equation

HRID 2246328 reaction equation
Cl[C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:9][C:10]1[CH:14]=[CH:13][N:12]([CH3:15])[N:11]=1.Cl[C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([OH:27])[CH:25]=2)[N:20]=[CH:19][N:18]=1>>[CH3:15][N:12]1[CH:13]=[CH:14][C:10]([NH:9][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([O:27][C:2]4[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][N:3]=4)[CH:25]=3)[N:20]=[CH:19][N:18]=2)=[N:11]1

Participants

4

Reactant 3

HCID 876032-Chloro-3-methylpyridineHCID 1372541-Methyl-3-aminopyrazoleHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160276HCID 23160276, compound

Procedure

The compound of Example 121 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2-chloro-3-methylpyridine, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-04d37e9e05894e40bead5e16137b3bc1
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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