2,6-Difluoropyridine → HCID 23160364, compound

HRID 2246335Notes

Reaction equation

HRID 2246335 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[N:3]=1.[NH2:9][C:10]1[CH:14]=[CH:13][N:12]([CH3:15])[N:11]=1.Cl[C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([OH:27])[CH:25]=2)[N:20]=[CH:19][N:18]=1>>[F:8][C:4]1[N:3]=[C:2]([O:27][C:24]2[CH:25]=[C:26]3[C:21](=[CH:22][CH:23]=2)[N:20]=[CH:19][N:18]=[C:17]3[NH:9][C:10]2[CH:14]=[CH:13][N:12]([CH3:15])[N:11]=2)[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 739342,6-DifluoropyridineHCID 1372541-Methyl-3-aminopyrazoleHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160364HCID 23160364, compound

Procedure

The compound of Example 128 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,6-difluoropyridine, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-cd84aabdf0cf4659b839828ab288585f
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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