2,3-Difluorobenzonitrile → 3-Fluoro-2-({4-[(1-pyridin-2-yl-1H-pyrazol-3-yl)-amino]quinazolin-6-yl}oxy)benzonitrile
Reaction equation
F[C:2]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:11][C:12]1[CH:16]=[CH:15][N:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[N:13]=1.Cl[C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[C:31]([OH:34])[CH:32]=2)[N:27]=[CH:26][N:25]=1>>[F:10][C:9]1[C:2]([O:34][C:31]2[CH:32]=[C:33]3[C:28](=[CH:29][CH:30]=2)[N:27]=[CH:26][N:25]=[C:24]3[NH:11][C:12]2[CH:16]=[CH:15][N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:13]=2)=[C:3]([CH:6]=[CH:7][CH:8]=1)[C:4]#[N:5]Participants
4
Procedure
The compound of Example 133 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,3-difluorobenzonitrile, 3-amino-1-(pyridin-2-yl)-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.
Sources & evidence
- ORD record
- ord-47d7545b5ee14eba92529c80c192c63a
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07687502B2
Reaction notes
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