HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Difluorobenzonitrile → 3-Fluoro-2-({4-[(1-pyridin-2-yl-1H-pyrazol-3-yl)-amino]quinazolin-6-yl}oxy)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Difluorobenzonitrile | HCID 88935 | — |
| Reactant | 1-(Pyridin-2-yl)-1H-pyrazol-3-amine | HCID 13496627 | — |
| Reactant | 4-Chloroquinazolin-6-ol | HCID 23160273 | — |
| Product | 3-Fluoro-2-({4-[(1-pyridin-2-yl-1H-pyrazol-3-yl)-amino]quinazolin-6-yl}oxy)benzonitrile | HCID 23160314 | — |
Reaction Steps
The compound of Example 133 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,3-difluorobenzonitrile, 3-amino-1-(pyridin-2-yl)-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687502B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-47d7545b5ee14eba92529c80c192c63a |
| Source note | uspto-grants-2010_03 |