Aminopyridazine → HCID 23160298, compound

HRID 2246346Notes

Reaction equation

HRID 2246346 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([CH3:11])(=[O:10])=[O:9])[C:3]=1F.[NH2:13][C:14]1[N:15]=[N:16][CH:17]=[CH:18][CH:19]=1.Cl[C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([OH:31])[CH:29]=2)[N:24]=[CH:23][N:22]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([CH3:11])(=[O:10])=[O:9])[C:3]=1[O:31][C:28]1[CH:29]=[C:30]2[C:25](=[CH:26][CH:27]=1)[N:24]=[CH:23][N:22]=[C:21]2[NH:13][C:14]1[N:15]=[N:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 3

HCID 230373AminopyridazineHCID 22747447HCID 22747447, compoundHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160298HCID 23160298, compound

Procedure

The compound of Example 143 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 1,2-difluoro-3-(methylsulfonyl)benzene, 3-amino-pyridazine and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-4104c95b05314e188f9dce27e89ac95a
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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