HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → [4-cyano-6-(4-ethoxy-3-trifluoromethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-ylmethyl]-triphenyl-phosphonium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-chloromethyl-6-(4-ethoxy-3-trifluoromethyl-phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile | HCID 58938114 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [4-cyano-6-(4-ethoxy-3-trifluoromethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-ylmethyl]-triphenyl-phosphonium chloride | HCID 86613868 | — |
Reaction Steps
2-Chloromethyl-6-(4-ethoxy-3-trifluoromethyl-phenyl)-1H-imidazo[4,5,c]-pyridine-4-carbonitrile (100 mg, 0.26 mmol) and triphenylphosphine in acetonitrile were heated to 60° C. and stirred overnight. The reaction mixture was concentrated and triturated with ether to give a light yellow solid. MS m/z 607.5 (m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687515B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-530339d8bb8447a2a8bb3edc4fa03adb |
| Source note | uspto-grants-2010_03 |