HRID2246449

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

结构：CCOc1ccc(-c2cc3[nH]c(CCl)nc3c(C#N)n2)cc1C(F)(F)F

HCID58938114

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(-c2cc3[nH]c(C[P+](c4ccccc4)(c4ccccc4)c4ccccc4)nc3c(C#N)n2)cc1C(F)(F)F.[Cl-]

HCID86613868

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

2-Chloromethyl-6-(4-ethoxy-3-trifluoromethyl-phenyl)-1H-imidazo[4,5,c]-pyridine-4-carbonitrile (100 mg, 0.26 mmol) and triphenylphosphine in acetonitrile were heated to 60° C. and stirred overnight. The reaction mixture was concentrated and triturated with ether to give a light yellow solid. MS m/z 607.5 (m).

WORKUP

后处理

concentrationThe reaction mixture was concentrated
customtriturated with ether
customto give a light yellow solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-530339d8bb8447a2a8bb3edc4fa03adb
来源数据集: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07687515B2
来源说明: uspto-grants-2010_03

反应 SMILES

[Cl:1][CH2:2][C:3]1[NH:4][C:5]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH3:19])=[C:13]([C:20]([F:23])([F:22])[F:21])[CH:12]=3)[N:8]=[C:7]([C:24]#[N:25])[C:6]=2[N:26]=1.[C:27]1([P:33]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>C(#N)C>[Cl-:1].[C:24]([C:7]1[C:6]2[N:26]=[C:3]([CH2:2][P+:33]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[NH:4][C:5]=2[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH3:19])=[C:13]([C:20]([F:23])([F:22])[F:21])[CH:12]=2)[N:8]=1)#[N:25]