HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 6-(4-ethoxy-3-trifluoromethyl-phenyl)-2-(3-morpholin-4-yl-propenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2-(3-Chloro-propenyl)-6-(4-ethoxy-3-trifluoromethyl-phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile | HCID 68517725 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-(4-ethoxy-3-trifluoromethyl-phenyl)-2-(3-morpholin-4-yl-propenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile | HCID 68514837 | — |
Reaction Steps
A solution of 2-(3-chloro-propenyl)-6-(4-ethoxy-3-trifluoromethyl-phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile (23 mg, 0.05 mmol), morpholine (16.1 mg, 0.15 mmol) in DMSO (500 uL) was heated to 120° C. for 5 minutes. The mixture was purified using ion exchange chromatography to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687515B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-b8728bcf47e24dc1a017e8783a870a12 |
| Source note | uspto-grants-2010_03 |