Ethanol → HCID 74438044, compound

HRID 2246556Notes

Reaction equation

HRID 2246556 reaction equation
[CH2:1]([C:3]1([O:35]C(=O)OCC2C=CC=CC=2)[C:8]2[CH:9]=[C:10]3[N:18]([C:19](=[O:20])[C:7]=2[CH2:6][O:5][C:4]1=[O:34])[CH2:17][C:16]1[C:15]([CH2:21][CH2:22][Si:23]([CH2:26][CH2:27][CH2:28][OH:29])([CH3:25])[CH3:24])=[C:14]2[CH:30]=[CH:31][CH:32]=[CH:33][C:13]2=[N:12][C:11]3=1)[CH3:2].[H][H].[CH2:48]([OH:50])[CH3:49]>[Pd]>[CH2:1]([C:3]1([OH:35])[C:8]2[CH:9]=[C:10]3[N:18]([C:19](=[O:20])[C:7]=2[CH2:6][O:5][C:4]1=[O:34])[CH2:17][C:16]1[C:15]([CH2:21][CH2:22][Si:23]([CH3:25])([CH3:24])[CH2:26][CH2:27][CH2:28][O:29][C:48](=[O:50])[C:49]2[CH:7]=[CH:8][CH:3]=[CH:1][CH:2]=2)=[C:14]2[CH:30]=[CH:31][CH:32]=[CH:33][C:13]2=[N:12][C:11]3=1)[CH3:2]

Participants

5

Reactant 3

HCID 702EthanolHCID 68530161HCID 68530161, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 74438044HCID 74438044, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of Compound 53 (20 mg, 0.027 mmol), 10% palladium on carbon (4 mg, 20%) in 1 mL of ethanol was hydrogenated for 17 hours at a balloon pressure of hydrogen at 21° C. The catalyst was removed by filtration over celite and the filtrate was evaporated to give a crude product, which was chromatographed to give the desired product.

Workup

  1. customThe catalyst was removed by filtration over celite
  2. customthe filtrate was evaporated
  3. customto give a crude product, which
  4. customwas chromatographed

Sources & evidence

ORD record
ord-7ddb255d8e1644c9a7683cd026511c28
Source dataset
uspto-grants-2010_03
Patent number
US07687496B2

Reaction notes

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