反应详情

Iodine (1.35 g) was added to a stirred solution of N-ethyl-3-(1H-indazol-6-yl)-4-methylbenzamide (Intermediate 12, 1.1 g) in 1,4-dioxan (20 ml) and aqueous sodium hydroxide (2M, 20 ml) then stirred at room temperature for 10 min. The reaction mixture was treated with aqueous sodium bisulphite (10%, 25 ml) and aqueous citric acid (10%, 25 ml). The mixture was extracted with ethyl acetate (3×25 ml) and the organic extracts were washed with water (30 ml) dried (Na2SO4) and concentrated under vacuum to give the title-compound (1.54 g).

1. extractionThe mixture was extracted with ethyl acetate (3×25 ml)
2. washthe organic extracts were washed with water (30 ml)
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated under vacuum