反应详情

Trifluoroacetic acid (2.73 ml) was added dropwise to a solution of 1,1-dimethylethyl 4-(6-{5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}-1H-indazol-3-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (Intermediate 20, 50 mg) in dichloromethane (10 ml) at room temperature under nitrogen then stirred at room temperature for 1 h. More trifluoroacetic acid (1.73 ml) was added and the mixture was stirred at room temperature under nitrogen for a further 1 h. The solvent was removed and the residue was dissolved in methanol and applied to an SCX ion exchange cartridge. Elution with a solution of ammonia (0.88) in methanol gave the title compound as a white solid (1.15 g).

1. stirringthe mixture was stirred at room temperature under nitrogen for a further 1 h
2. customThe solvent was removed
3. dissolutionthe residue was dissolved in methanol
4. washElution with a solution of ammonia (0.88) in methanol